Journal
JOURNAL OF BACTERIOLOGY
Volume 189, Issue 4, Pages 1464-1467Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01153-06
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Funding
- NINDS NIH HHS [R01 NS051247, R01 NS051247-01A1] Funding Source: Medline
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Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.
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