Journal
ANGIOLOGY
Volume 65, Issue 8, Pages 667-676Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319713506516
Keywords
oxidative stress; free radicals; acute brain ischemia; stroke
Categories
Funding
- Ministry of Education and Science, Republic of Serbia [41002, 173033]
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The pathogenesis of acute brain ischemia (ABI) is highly complex and involves multiple mechanisms including free radical generation. Imbalance between the cellular production of free radicals and the ability of cells to defend against them is referred to as oxidative stress. Oxidative stress is one of the mechanisms contributing to neuronal damage, potentially induced through the ABI. Through interactions with a large number of molecules, reactive oxygen species may irreversibly destroy or alter the function of the cellular lipids, proteins, and nucleic acids and initiate cell signaling pathways after cerebral ischemia. Future investigations should focus on the understanding of oxidative stress mechanisms and neuro-protection in order to discover new treatment targets.
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