Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 11, Issue 2, Pages 133-144Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.11.2.133
Keywords
apoptosis; drug resistance; I kappa B kinase; NF-kappa B; NSAID; proteasome; target therapy
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NF-kappa B transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the different types of inhibitors targeting the NF-kappa B pathway at several stages.
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