Journal
CURRENT MOLECULAR MEDICINE
Volume 7, Issue 1, Pages 121-131Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652407779940495
Keywords
-
Categories
Funding
- NCI NIH HHS [CA121904, CA113655] Funding Source: Medline
Ask authors/readers for more resources
The better part of a century has passed since Otto Warburg first hypothesized that unique phenotypic characteristics of tumor cells might be associated with an impairment in the respiratory capacity of these cells. Since then a number of distinct differences between the mitochondria of normal cells and cancer cells have been observed at the genetic, molecular, and biochemical levels. This article begins with a general overview of mitochondrial structure and function, and then outlines more specifically the metabolic and molecular alterations in mitochondria associated with human cancer and their clinical implications. Special emphasis is placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available