Journal
GENETICS
Volume 175, Issue 2, Pages 777-783Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.106.065318
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Funding
- NICHD NIH HHS [HD38921, R01 HD038921] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007617, T32GM007617] Funding Source: Medline
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In Drosophila melanogaster, seminal fluid regulates the reproductive and immune responses of mated females. Some seminal fluid proteins may provide protective functions to mated females, such as antimicrobial activity and/or stimulation of antimicrobial gene expression levels, while others appear to have negative effects, contributing to a cost of mating. To identify seminal proteins that could participate in these phenomena, we used a systemic ectopic expression screen to test the effects oil unmated females of proteins normally produced by the male accessory gland (Acps). Of the 21 ectopically expressed Acps that we tested for ability to assist in the clearance of a bacterial infection with Serratia marcescens, 3 Acps significantly reduced the bacterial counts of infected females, suggesting a protective role. Of the 23 Acps that we tested for toxicity, 3 were toxic, including one that has been implicated in the cost of mating in another study We also tested ectopic expression females for other Acp-induced effects, but found no additional Acps that affected egg laying or receptivity upon ectopic expression.
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