Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 22, Issue 1, Pages 3-13Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730406296749
Keywords
circadian; suprachiasmatic; vasopressm; VIP; structure; NPY; serotonin; RHT
Categories
Funding
- NIMH NIH HHS [MH64471, R01 MH064471, R01 MH064471-04] Funding Source: Medline
- NINDS NIH HHS [NS22168, R01 NS022168-21, R01 NS022168] Funding Source: Medline
Ask authors/readers for more resources
The SCN has long had organizational schemas imposed on it. In most, the SCN is dichotomized, with one region typically associated with the presence of vasopressin cells and the other associated with cells containing vasoactive intestinal polypeptide and certain afferent terminal fields. If assumed to be accurate, the schemas that have been intended to simplify and conceptually organize the known anatomy may actually interfere with the understanding of how various cell types and input pathways contribute to circadian rhythm regulation. This review describes inadequacies of existing schemas and notes several practical difficulties that undermine their usefulness. These include static versus dynamic anatomy, generalizations about SCN organization in relation to the plane or level of section, and the concept of differential density, all of which contribute to a view in which the SCN is substantially more complex than typically depicted in oversimplified line drawings. The need for accurate topographical description is emphasized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available