Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 1, Pages 66-72Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2006.11.017
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Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.
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