Journal
ANGIOLOGY
Volume 64, Issue 8, Pages 609-613Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319712461930
Keywords
photoplethysmography; Raynaud phenomenon; reflex index; improvement pattern of PPG
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We assessed the utility of a 3-grade classification of photoplethysmography (PPG) with cold water provocation test in Raynaud phenomenon (RP). A total of 35 patients with RP and 38 healthy volunteers were recruited. In healthy volunteers, PPG was measured twice at intervals of 30 minutes for evaluating reproducibility of test. Percentage variation of the PPG amplitude in post- versus precold provocation was expressed on a 3-grade scale at 1, 3, and 5 minutes (reflection index: RI) in patients with RP. The improvement pattern of the PPG (IPPPG) was evaluated by summing the score differences from RI1min to RI3min and RI5min. After a therapeutic period of 8 weeks with nifedipine, the decreases in posttherapeutic RI3min and RI5min were statistically significant (P < .05). Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P < .05). The analysis of cold-provoked PPG waves demonstrated and quantified improvements in peripheral arterial circulation in RP.
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