Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 39, Issue 1, Pages 79-84Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-006-9063-9
Keywords
extrinsic apoptotic pathways; intrinsic apoptotic pathways; galectin-3; modified citrus pectin
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Funding
- NCI NIH HHS [R37CA46120-19, R01 CA046120] Funding Source: Medline
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During the past decade, extensive progress has been made toward understanding the molecular basis for the regulation of apoptosis. In mammalian cells undergoing apoptosis, two distinct mechanisms or pathways are operated and are triggered by cell death stimuli from intra- or extra-cellular environments, namely the intrinsic or extrinsic pathways, resulting in mitochondrial membrane depolarization. Several lines of evidence from our laboratories and others have indicated that galectin-3 plays an important role in these pathways by binding to various ligands. Here the authors provide a brief discussion on the role of endogenous or extra-cellular galectin-3 in the regulation of apoptosis and how it could be used as a therapeutic target using natural plant products as its functional inhibitors.
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