Journal
SEMINARS IN CANCER BIOLOGY
Volume 17, Issue 1, Pages 42-55Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2006.10.005
Keywords
cancer; gene amplification; cell-lineage specificity; selection; clinical significance
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DNA copy number amplifications activate oncogenes and are found in the majority of advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications in cancer suggest that properties of precursor stem cells and selection pressure in the tissue microenvironment determine the genomic location of gene amplifications. Biological specificity and significance of gene amplifications make them potential targets for clinical applications. Here we discuss the specificity of non-randomly occurring DNA copy number amplifications as defining features for cancers, their selection in the tumor tissue, and significance in the clinical practice. (c) 2006 Elsevier Ltd. All rights reserved.
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