Journal
ACS CHEMICAL BIOLOGY
Volume 2, Issue 2, Pages 99-103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb700021z
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Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in cancer. Three new crystal structures of PP2A show how it interacts with inhibitory toxins and with one of its regulatory subunits. The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes.
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