Journal
SCHIZOPHRENIA RESEARCH
Volume 90, Issue 1-3, Pages 308-315Publisher
ELSEVIER
DOI: 10.1016/j.schres.2006.10.005
Keywords
schizophrenia; attention; cingulum bundle
Categories
Funding
- NIMH NIH HHS [R01 MH 40799, R01 MH063360, K02 MH 01110, R01 MH 50747, R01 MH 63360, R01 MH050740, R01 MH040799, R03 MH068464, R03 MH068464-01] Funding Source: Medline
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Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n = 18) also had available magnetic resonance diffusion tensor imaging (DTI) measures of the cingulum bundle (CB) fractional anisotropy and volume. The patients showed a significantly different pattern of ANT performance, characterized primarily by decreased alerting efficiency. In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration. (c) 2006 Elsevier B.V. All rights reserved.
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