Journal
VETERINARY RESEARCH
Volume 38, Issue 2, Pages 229-241Publisher
BMC
DOI: 10.1051/vetres:200661
Keywords
pseudorabies virus; virus replication; cell-associated spread; pathogenesis; control
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In the present review, several cell biological and molecular aspects of virus-cell and virus-host (pig) interactions are reviewed for pseudorabies (Aujeszky's disease) virus. Concerning the virus-cell interactions, the complex cascade of events in the virus replication cycle is given together with the different mechanisms of cell-to-cell spread. The pathogenesis of pseudorabies virus infections in pigs is concentrated on the sequence of events in the respiratory tract. Finally, a short overview is given on the control of the disease and eradication of the virus by the combination of marker vaccines and discriminating ELISA.
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