Journal
ANGIOLOGY
Volume 61, Issue 6, Pages 557-566Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319709356424
Keywords
curcumin; pancreatic islets; heme oxygenase; insulin secretion
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Funding
- Science and Technology Development Fund
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Curcumin exerts a hypoglycemic action and induces heme-oxygenase-I (HO-I). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-I. Islets were isolated from rats and divided into control islets, islets incubated in different curcumin concentrations, islets incubated in hemin, islets incubated in curcumin and HO inhibitor, stannous mesoporphyrin (SnMP), islets incubated in hemin and SnMP, islets incubated in SnMP only, and islets incubated in 16.7 mmol/L glucose. Heme-oxygenase activity, HO-I expression, and insulin estimation was assessed. Insulin secretion, HO-I gene expression and HO activity were significantly increased in islets incubated in curcunnin, hemin, and glucose compared with controls. This increase in insulin secretion was significantly decreased by incubation of islets in SnMP. The action of curcumin on insulin secretion from the isolated islets may be, in part, mediated through increased HO-I gene expression.
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