Journal
NEUROSCIENCE RESEARCH
Volume 57, Issue 2, Pages 326-329Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2006.10.015
Keywords
cell division; neuronal migration; cerebral cortex; ventricular zone; centrosome; slice culture; mouse
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Recent imaging studies revealed that neocortical neurons undergo multiple modes of migration, but their earliest morphologies and behaviors remain unclear. We found that some neurons generated at the ventricular surface initially adopt a pin-like morphology and generally lack a leading process. During abventricular nuclear movement, their centrosomes are localized to the ventricular endfoot. Their detachment from the germinal zone is accomplished by retraction of the ventricular process, which is frequently accompanied by an adventricular somal movement, suggesting that a pulling force within the process might function to contract the cell. Subsequently, they become multipolar upon entry into the subventricular zone. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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