Journal
PATHOLOGIE BIOLOGIE
Volume 55, Issue 1, Pages 37-48Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.patbio.2006.04.007
Keywords
trisomy 8; acute myeloid leukemia; myelodysplastic syndrome; sole chromosomal aberration
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Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change. (c) 2006 Elsevier Masson SAS. All rights reserved.
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