Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 17, Issue 2, Pages 48-54Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2006.11.005
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Funding
- NHLBI NIH HHS [P01 HL075209, R37 HL038206, R01 HL038206, R01 HL058863, P01 HL058000] Funding Source: Medline
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The development of vascular disease has its origins in an initial insult to the vessel wall by biological or mechanical factors. The disruption of homeostatic mechanisms leads to alteration of the original architecture of the vessel and its biological responsiveness, contributing to acute or chronic diseases such as stroke, hypertension, and atherosclerosis. Endothelial dysfunction, macrophage infiltration of the vessel wall, and proliferation and migration of smooth muscle cells all involve different types of reactive oxygen species produced by various vessel wall components. Although basic science and animal research have clearly established the role of reactive oxygen species in the progression of vascular disease, the failure of clinical trials with antioxidant compounds has underscored the need for better antioxidant therapies and a more thorough understanding of the role of reactive oxygen species in cardiovascular physiology and pathology. (c) 2007, Elsevier Inc.
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