Journal
DEVELOPMENTAL BIOLOGY
Volume 302, Issue 1, Pages 13-24Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2006.08.049
Keywords
Sry; sex determination; molecular mechanism; evolution; testis development; brain gender
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In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discovered, and the mechanisms by which it mediates its developmental functions are still elusive. What is clear is that instead of the robust gene one might expect as the pillar of male sexual development, Sry function hangs by a thin thread, a situation that has profound biological, medical and evolutionary implications. (c) 2006 Elsevier Inc. All rights reserved.
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