Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 38, Pages 12519-12523Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201807373
Keywords
amphiphilic calixarenes; cucurbituril; lysosome-targeted cell imaging; near-IR supramolecular assemblies
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Funding
- NNSFC [21672113, 21432004, 21772099, 21861132001, 91527301]
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A two-stage mediated near-infrared (NIR) emissive supramolecular assembly for lysosome-targeted cell imaging is presented. 4,4-Anthracene-9,10-diylbis(ethene-2,1-diyl))bis(1-ethylpyridin-1-ium) bromide (ENDT) was synthesized as an organic dye with weak fluorescence emission at 625nm. When ENDT complexes with cucurbit[8]uril (CB[8]), this binary supramolecular complex assembles into nanorods with a near-infrared fluorescence emission (655nm) and fluorescence enhancement as the first stage. Such supramolecular complexes interact with lower-rim dodecyl-modified sulfonatocalix[4]arene (SC4AD) to form nanoparticles for further fluorescence enhancement as the second stage. Furthermore, based on a co-staining experiment with LysoTracker Blue, such nanoparticles can be applied in NIR lysosome-targeted cell imaging.
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