Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 38, Pages 12504-12507Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201807223
Keywords
crystallography; DNA nanotechnology; porous materials; self-assembled crystals
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Funding
- Howard Hughes Medical Institute. The Advanced Light Source is a Department of Energy Office of Science User Facility [DE-AC02-05CH11231]
- National Institute of Health, National Institute of General Medical Sciences (NIGMS) through a Biomedical Technology Research Resource P41 grant [P41GM111244]
- DOE Office of Biological and Environmental Research [KP1605010]
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Program [DE-SC0012704, KC0401040]
- NSF [1360635, 1334109]
- ARO [W911NF-12-1-0420]
- NIH [R01GM104960]
- Presidential Strategic Initiative Fund from Arizona State University
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1360635] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1334109] Funding Source: National Science Foundation
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Programming self-assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self-assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21-base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson-Crick base-pairing. The six-fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self-assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well-defined cavities that are suitable for future applications with immobilized guests.
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