Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 18, Issue 1-2, Pages 33-43Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.01.004
Keywords
lymphocyte homing; chemokines
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Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naive, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues. (c) 2007 Published by Elsevier Ltd.
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