Journal
JOURNAL OF BACTERIOLOGY
Volume 189, Issue 4, Pages 1459-1463Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01026-06
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The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.
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