Journal
JOURNAL OF IMMUNOLOGY
Volume 178, Issue 3, Pages 1564-1572Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.3.1564
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Funding
- NIAID NIH HHS [R01AI06877-01, R21AI070038-01] Funding Source: Medline
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We previously showed that immunization with a combination of TLR and CD40 agonists (combined TLR/CD40 agonist immunization) resulted in an expansion of Ag-specific CD8 T cells exponentially greater than the expansion observed to immunization with either agonist alone. We now show that the mechanism behind this expansion of T cells is the regulated expression of CD70 on dendritic cells. In contrast to previous results in vitro, the expression of CD70 on dendritic cells in vivo requires combined TLR/CD40 stimulation and is not significantly induced by stimulation of either pathway alone. Moreover, the exponential expansion of CD8(+) T cells following combined TLR/CD40 agonist immunization is CD70 dependent. Thus, the transition from innate stimuli (TLRs) to adaptive immunity is controlled by the regulated expression of CD70.
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