Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 40, Pages 13266-13270Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201807144
Keywords
C-H functionalization; fluorine; reaction mechanisms; silver; synthetic methods
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Funding
- State Key Laboratory of Elemento-organic Chemistry
- National Key Research and Development Program of China [2016YFA0602900, 2018YFA0306002]
- NFSC [21522205, 21672110]
- Fundamental Research Funds for the Central Universities
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A silver-promoted oxidative benzylic C-H trifluoromethoxylation has been reported for the first time. With trifluoromethyl arylsulfonate as the trifluoromethoxylation reagent, various arenes, having diverse functional groups, undergo trifluoromethoxylation of their benzylic C-H bonds to form trifluoromethyl ethers under mild reaction conditions. In addition, the trifluoromethoxylation and the fluorination of methyl groups of electron-rich arenes have been achieved to prepare -fluorobenzyl trifluoromethyl ethers in one step.
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