Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 40, Pages 13114-13119Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201807158
Keywords
conjugated polymer nanoparticles; drug delivery; imaging; photo-responsive systems
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Funding
- Chinese Academy of Sciences [XDA16020804]
- National Natural Science Foundation of China [91527306, 21533012, 21661132006]
- PIFI-Postdoctoral fellowship of Chinese Academy of Sciences
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Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, photo-responsive conjugated polymer nanoparticles (CPNs) functionalized with donor-acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery and imaging are reported. Upon visible-light (lambda=550nm) irradiation, CPNs simultaneously undergo structure, color, and polarity changes that release encapsulated drugs into the cells. The backbone of CPNs favors FRET to DASA units boosting their fluorescence. Notably, drug-loaded CPNs exhibit excellent biocompatibility in the dark, indicating perfect control of the light trigger over drug release. Delivery of both hydrophilic and hydrophobic drugs with good loading efficiency was demonstrated. This strategy enables remotely controlled drug delivery with visible-light irradiation, which sets an example for designing delivery vehicles for non-invasive therapeutics.
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