Journal
PLOS GENETICS
Volume 3, Issue 2, Pages 319-323Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.0030032
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Funding
- NHGRI NIH HHS [T32 HG00035, T32 HG000035] Funding Source: Medline
- NIGMS NIH HHS [R01 GM57070, R01 GM057070, R01 GM057070-10] Funding Source: Medline
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Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.
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