Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 39, Pages 12733-12736Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806966
Keywords
F-18-fluorination; photocatalysis; peptides; PET imaging; radiolabeling
Categories
Funding
- NSERC Discovery Grant
- MSFHR Career Investigator Award
- MSFHR I2I Grant
- Hoffmann-La Roche Fellowship
- CCSRI Innovation Grant
- National Research Council of Canada
Ask authors/readers for more resources
Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling unmodified peptides with F-18 for positron emission tomography (PET) imaging presents a number of challenges. Here we show the combination of photoactivated sodium decatungstate and [F-18]-N-fluorobenzenesulfonimide effects site-selective F-18-fluorination at the branched position in leucine residues in unprotected and unaltered peptides. This streamlined process provides a means to directly convert native peptides into PET imaging agents under mild aqueous conditions, enabling rapid discovery and development of peptide-based molecular imaging tools.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available