Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 39, Pages 12680-12684Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805707
Keywords
coordination polymers; MRI contrast agents; polyelectrolytes micelles; tunable stability and properties
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Funding
- Shanghai Municipal Natural Science Foundation [17ZR1440500, 17PJ1401800]
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Three-component mixtures (diblock copolymer/metal ion/oligoligand) can assemble into micellar particles owing to a combination of supramolecular polymerization and electrostatic complex formation. Such particles cover a large range of compositions, but the electrostatic forces keeping them together make them rather susceptible to disintegration by added salt. Now it is shown how the salt stability can be tuned continuously by employing both a bis-ligand and a tris-ligand, and varying the ratio of these in the mixture. For magnetic ions such as Mn-II and Fe-III, the choice of the multiligand also affects the ion/water interaction and, hence, the magnetic relaxivity. As an example, Mn-II-based nanoparticles with a very high longitudinal relaxivity (10.8 mm(-1) s(-1)) were investigated that are not only biocompatible but also feature strong contrast enhancement in target organs (liver, kidney), as shown by T-1-weighted invivo magnetic resonance imaging (MRI).
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