Journal
FASEB JOURNAL
Volume 21, Issue 2, Pages 325-332Publisher
WILEY
DOI: 10.1096/fj.06-7227rev
Keywords
anti-inflammatories; leukocytes; lipid mediators; chemokines; cytokines
Categories
Funding
- MRC [G0601481, G116/131] Funding Source: UKRI
- Medical Research Council [G0601481, G9818340B, G116/131] Funding Source: researchfish
- Arthritis Research UK [16390] Funding Source: Medline
- Medical Research Council [G116/131, G0601481] Funding Source: Medline
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A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution.
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