Journal
BIOMATERIALS
Volume 28, Issue 4, Pages 710-716Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.09.014
Keywords
magnetite nanoparticles; lactobionic acid; maltotrionic acid; intracellular uptake; hepatocytes; particle internalization
Funding
- Korea Institute of Industrial Technology(KITECH) [A04-01] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과06B1508] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the current study, superparamagnetic magnetite nanoparticles were surface-modified with lactobionic acid (LA) to improve their intracellular uptake and ability to target hepatocytes. Maltotrionic acid (MA)-modified nanoparticles were also synthesized as a control. Cell culture experiment showed that LA-modified nanoparticles were internalized into hepatocytes and atomic absorption spectrometer (AAS) measurement indicated that the uptake amount of LA-modified magnetite into hepatocytes was higher than that of unmodified and MA-modified nanoparticles. LA-modified nanoparticle solution was injected in rabbit and the magnetic resonance (MR) images obtained showed that LA-coated nanoparticles were selectively accumulated onto the hepatocytes. This result demonstrates that the LA-modified magnetite nanoparticles have a great potential to be used as contrast agent for liver diagnosis. (c) 2006 Elsevier Ltd. All rights reserved.
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