Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 17, Issue 1, Pages 15-22Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2006.12.004
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA104282, R01 CA72614] Funding Source: Medline
Ask authors/readers for more resources
Ras proteins regulate cell proliferation, survival and differentiation and are constitutively activated by somatic point mutations in many cancers. Previous Studies of neurofibromatosis type 1 and Noonan syndrome also implicated hyperactive Ras in developmental disorders. Recently, germline mutations in H-RAS and K-RAS and in genes encoding other molecules in the Ras-Raf-MEK-ERK cascade were shown to underlie cases of Noonan, cardio-facio-cutaneous, and Costello syndromes. These disorders share phenotypic traits that include abnormal facial features, heart defects, and impaired growth and development. Many of these germline, disease-associated mutations encode novel Ras, Raf and MEK proteins. These studies underscore a crucial role of Ras signaling in human development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available