Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 1, Pages 42-48Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808438
Keywords
biomimesis; biosyntheses; mineral surfaces; origin of life; purine and pyrimidine
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The origin of life is mostly divided into genetics first and metabolism first hypotheses. The former is based on spark-tube tests and organic species from meteorites and comets, and proposes a heterotrophic origin of life also consistent with the RNA World concept. The metabolism first hypothesis posits that life began autotrophically on minerals and/or hydrothermal vents. The lack of direct evidence means it is not possible to lend solid support to either hypothesis but the metabolism first option can be explored if a continuous geochemical, catalytically dynamic process is assumed. Using this approach, it is speculated that purine and pyrimidine synthesis originated on a mineral surface, which was later replaced by ATP. The same applies to redox processes where metal-bound hydrides could have been replaced by NAD.
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