Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 43, Pages 14121-14124Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808534
Keywords
allostery; cage compounds; host-guest systems; multivalency; self-assembly
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Funding
- Royal Commission for the Exhibition of 1851 Research Fellowship
- UK Engineering and Physical Sciences Research Council [EPSRC EP/P027067/1]
- European Research Council [695009]
- Deutsche Forschungsgemeinschaft [SFB 765]
- Gates Cambridge Scholarship
- EPSRC [EP/P027067/1] Funding Source: UKRI
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We report a strategy for regulating the rate of internally bound anion exchange within an Fe4L6 metal-organic tetrahedron through external coordination of tripodal tris(alkylammonium) cations. The cage features three flexible 18-crown-6 receptors at each of its Fe-II vertices, facilitating strong tritopic interactions with tris(ammonium) cations to cap the vertices of the tetrahedron. This capping mechanism restricts the flexibility of the cage framework, thereby reducing the rate of anion exchange within its central cavity by 20-fold. Thus, we demonstrate the first use of an externally bound multivalent effector to allosterically control internal guest binding in a molecular cage.
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