Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 1, Pages 99-110Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2006.10.042
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Funding
- NIDDK NIH HHS [R01 DK054257-08] Funding Source: Medline
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The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements in this area have included the expansion of transgene activation through ligand-receptor engineering, drug development from structural design and the exploitation of innate ligand-specific associations towards developing novel conditional protein-based recombinant and diagnostic tools. These advancements come on the heels of exciting new modes of hormone action that challenge and expand upon the classic paradigms of hormone receptor function.
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