Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 2, Pages 274-285Publisher
WILEY
DOI: 10.1359/JBMR.061110
Keywords
intestinal calcium absorption; renal excretion; TRPV6; alopecia; vitamin D
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Funding
- NCI NIH HHS [CA101075, R01 CA101075] Funding Source: Medline
- NIAMS NIH HHS [P01AR39488, R01 AR051930] Funding Source: Medline
- NIDDK NIH HHS [R01 DK067155, R01 DK052005, DK52005, DK67155] Funding Source: Medline
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We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis, including defective intestinal Ca2+ absorption, increased urinary Ca2+ excretion, decreased BMD, deficient weight gain, and reduced fertility. Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction.
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