Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 9, Pages 2580-2605Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805501
Keywords
carbon-11; fluorine-18; nitrogen-13; oxygen-15; positron emission tomography
Categories
Funding
- NIH [DA038000, DA043507, MH117125, AG054473]
- NSFC [81701751]
- Fundamental Research Funds for the Central Universities [21617311]
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Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on C-11, F-18, N-13, and O-15.
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