Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 1, Pages 74-85Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808371
Keywords
dynamic covalent chemistry; dynamic materials; molecular assembly; molecular recognition; orthogonality
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Funding
- National Science Foundation through the Center for Dynamics and Control of Materials: an NSF MRSEC [DMR-1720595]
- DARPA Fold-F(x) program [N66001-14-2-4051]
- National Institutes of Health [1R01EB022025-01A1]
- Welch Regents Chair [F-0046]
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Dynamic assembly of macromolecules in biological systems is one of the fundamental processes that facilitates life. Although such assembly most commonly uses noncovalent interactions, a set of dynamic reactions involving reversible covalent bonding is actively being exploited for the design of functional materials, bottom-up assembly, and molecular machines. This Minireview highlights recent implementations and advancements in the area of tunable orthogonal reversible covalent (TORC) bonds for these purposes, and provides an outlook for their expansion, including the development of synthetically encoded polynucleotide mimics.
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