Journal
BREAST
Volume 16, Issue 1, Pages 104-107Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.breast.2006.09.003
Keywords
basal subtype of breast carcinomas; breast cancer; EGFR; HER2; targeted therapies
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The recent understanding of the molecular basis of breast cancer growth and progression led to the identification of tumor subtypes with potentially different biologic behavior. In addition, targeted therapies are increasingly successful in cancer treatment. We recently reported that most of the ER-negative/PR-negative/HER2-negative patients, a group that presents a therapeutic challenge for the oncologist, express EGFR. We now report that the majority of these patients express cytokeratin CK5/6 and therefore belong to the basal subtype of breast carcinomas. These basal subtype lesions are usually high-grade tumors of ductal histology with a high proliferation rate. We propose that the majority of the triple negative patients have basal subtype tumors with high EGFR expression and that these tumors may be the subgroup of breast carcinomas that could potentially benefit the most from novel EGFR-targeted therapeutic strategies. (c) 2006 Elsevier Ltd. All rights reserved.
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