Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 6, Pages 1780-1786Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201408476
Keywords
aggregation-induced emission (AIE); cancer; fluorescence imaging; image-guided therapy; photodynamic therapy
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Funding
- Ministry of Defense [R279-000-340-232]
- SMART [R279-000-378-592]
- Ministry of Education [R279-000-391-112]
- Institute of Materials Research and Engineering of Singapore [IMRE/12-8P1103]
- Research Grants Council of Hong Kong [HKUST2/CRF/10, N HKUST620/11]
- Guangdong Innovative Research Team Program [201101C0105067115]
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Activatable photosensitizers (PSs) have been widely used for the simultaneous fluorescence imaging and photodynamic ablation of cancer cells. However, the ready aggregation of traditional PSs in aqueous media can lead to fluorescence quenching as well as reduced phototoxicity even in the activated form. We have developed a series of PSs that show aggregation-enhanced emission and phototoxicity and thus the exact opposite behavior to that of previously reported PSs. We further developed a dual-targeted enzyme-activatable bioprobe based on the optimized photosensitizer and describe simultaneous light-up fluorescence imaging and activated photodynamic therapy for specific cancer cells. The design of smart probes should thus open new opportunities for targeted and image-guided photodynamic therapy.
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