Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 81, Issue 2, Pages 403-411Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0306194
Keywords
bacterial injection; IL-2; tumor necrosis factor-alpha
Categories
Funding
- NIAID NIH HHS [AI056172, AI055743] Funding Source: Medline
Ask authors/readers for more resources
A number of studies have documented suppression of lymphocyte activation in mice infected with Salmonella. Here, we describe incomplete activation of CD4+ T cells following intravenous injection of specific peptide and LPS into Salmonella-infected mice. Although antigen-specific CD4+ T cells were activated by peptide/LPS to increase surface CD69 expression, they did not produce IL-2 or TNF-alpha. Suppression of cytokine production did not require prolonged exposure of the T cells to the Salmonella-infected environment, was not antigen specific, but was dependent upon the presence of LPS during stimulation. These data suggest that Salmonella-infected mice are exquisitely sensitive to the generation of a suppressive environment following innate immune stimulation with LPS. In agreement with this interpretation, repeated low-dose administration of LPS caused uncontrolled replication of attenuated Salmonella in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available