Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 21, Pages 5380-5384Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402751
Keywords
cell adhesion; conducting materials; gels; nanoparticles; renewable resources
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Funding
- National Basic Research Program of China (973 Program) [2010CB732203, 2012CB619100]
- National Natural Science Foundation of China [51373125, 20904043, 51372085]
- State Key Program of National Natural Science of China [21334005]
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Nanostructured conductive polymers can offer analogous environments for extracellular matrix and induce cellular responses by electric stimulation, however, such materials often lack mechanical strength and tend to collapse under small stresses. We prepared electrically conductive nanoporous materials by coating nanoporous cellulose gels (NCG) with polypyrrole (PPy) nanoparticles, which were synthesized insitu from pyrrole monomers supplied as vapor. The resulting NCG/PPy composite hydrogels were converted to aerogels by drying with supercritical CO2, giving a density of 0.41-0.53gcm(-3), nitrogen adsorption surface areas of 264-303m(2)g(-1), and high mechanical strength. The NCG/PPy composite hydrogels exhibited an electrical conductivity of up to 0.08Scm(-1). Invitro studies showed that the incorporation of PPy into an NCG enhances the adhesion and proliferation of PC12 cells. Electrical stimulation demonstrated that PC12 cells attached and extended longer neurites when cultured on NCG/PPy composite gels with DBSA dopant. These materials are promising candidates for applications in nerve regeneration, carbon capture, catalyst supports, and many others.
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