4.8 Article

Plasmonic Liquid Marbles: A Miniature Substrate- less SERS Platform for Quantitative and Multiplex Ultratrace Molecular Detection**

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 20, Pages 5054-5058

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201401026

Keywords

liquid marbles; multiplex detection; sensors; surface-enhanced Raman spectroscopy; ultratrace detection

Funding

  1. National Research Foundation, Singapore [NRF-NRFF2012-04]
  2. Nanyang Technological University
  3. A*STAR, Singapore

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Inspired by aphids, liquid marbles have been studied extensively and have found application as isolated microreactors, as micropumps, and in sensing. However, current liquid-marble-based sensing methodologies are limited to qualitative colorimetry-based detection. Herein we describe the fabrication of a plasmonic liquid marble as a substrate-less analytical platform which, when coupled with ultrasensitive SERS, enables simultaneous multiplex quantification and the identification of ultratrace analytes across separate phases. Our plasmonic liquid marble demonstrates excellent mechanical stability and is suitable for the quantitative examination of ultratrace analytes, with detection limits as low as 0.3fmol, which corresponds to an analytical enhancement factor of 5x10(8). The results of our simultaneous detection scheme based on plasmonic liquid marbles and an aqueous-solid-organic interface quantitatively tally with those found for the individual detection of methylene blue and coumarin.

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