Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 183, Issue 1-2, Pages 7-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.10.018
Keywords
T cell; autoimmunity; multiple sclerosis; tolerance; antigen processing
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Funding
- MRC [G117/515] Funding Source: UKRI
- Medical Research Council [G117/515] Funding Source: Medline
- Medical Research Council [G117/515] Funding Source: researchfish
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We have assessed the complexity in T cell recognition of the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein (MOG) in C5713L/6 mice. Immunization with the p35-55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35-55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG. (c) 2006 Elsevier B.V.. All rights reserved.
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