Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 846, Issue 1-2, Pages 374-377Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2006.08.049
Keywords
4-bromo-2,5-dimethoxy-beta-phenethylamine; 2C-B; designer drug; metabolism; GC-MS
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The phenethylamine-derived designer drug 4-bromo-2,5-dimethoxy-a-phenethylamine (2C-B) is known to be extensively metabolized in various species including humans. In rat urine, 2C-B was found to be excreted mainly via its metabolites. In the current study, the toxicological detection of these metabolites in the authors' systematic toxicological analysis (STA) procedure was examined. The STA procedure using full-scan GC-MS allowed proving an intake of a common drug abusers' dose of 2C-B by detection of the O-demethyl deaminohydroxy and two isomers of the O-demethyl metabolites in rat urine. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of 2C-B in human urine. (c) 2006 Elsevier B.V. All rights reserved.
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