Development of Coated Blade Spray Ionization Mass Spectrometry for the Quantitation of Target Analytes Present in Complex Matrices

Coated blade spray (CBS) is a technology based on solid-phase microextraction (SPME) that has been designed for the quick extraction/cleanup of analytes from complex matrices and direct desorption/ionization under ambient mass spectrometry conditions. The entire analytical process can be completed in less than 3 min and enables limits of quantitation in the low picogram-per-milliliter region to be reached.