Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 30, Pages 7809-7813Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403918
Keywords
aggregation; cell recognition; fluorescence; imaging agents; molecular recognition
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Funding
- National Basic Research Program [2013CB834505, 2013CB834703, 2011CBA00905, 2009CB930802]
- National Natural Science Foundation of China [21233011, 91123033, 21273252, 21205122, 21261160488, 21072196]
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Adenosine 5'-triphosphate (ATP) is a multifunctional molecule that participates in many important biological processes. Currently, fluorescence indicators for ATP with high performance are in demand. Reported herein is a novel water-soluble triarylboron compound which displays an apparent ATP-dependent fluorescence enhancement when dispersed in water. It can selectively recognize ATP from other bioactive substances in vitro and in vivo. The ATP-induced finite aggregation endows the indicator with appreciable photostability and superior tolerance to environmental electrolytes. This indicator has been successfully applied to the ATP imaging in NIH/3T3 fibroblast cells. The difference in the ATP levels within the membrane and cytosol is clearly visible.
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