Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 45, Pages 12240-12243Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407452
Keywords
gas-phase reactions; low-energy electrons; mass spectrometry; metastable compounds; reaction mechanisms
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Funding
- Austrian Science Fund (FWF) [P22665]
- ARC via the ARC Centre of Excellence program
- Austrian Science Fund (FWF) [P 22665] Funding Source: researchfish
- Austrian Science Fund (FWF) [P22665] Funding Source: Austrian Science Fund (FWF)
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Low-energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4-nitroimidazole (4NI) by dissociative electron attachment (DEA). The reactions include simple bond cleavages but also complex reactions involving multiple bond cleavages and formation of new molecules. Both simple and complex reactions are associated with pronounced sharp features in the anionic yields, which are interpreted as vibrational Feshbach resonances acting as effective doorways for DEA. The remarkably rich chemistry of 4NI is completely blocked in 1-methyl-4-nitroimidazole (Me4NI), that is, upon methylation of 4NI at the N1 site. These remarkable results have also implications for the development of nitroimidazole based radiosensitizers in tumor radiation therapy.
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