Journal
MOLECULES
Volume 12, Issue 2, Pages 139-148Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL
DOI: 10.3390/12020139
Keywords
Staphylococcus aureus; fatty alcohols; antibacterial activity; length of carbon chain; K+ ion leakage
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The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
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