Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 3, Pages 734-744Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201404856
Keywords
aldehydes; alkenes; palladium; reaction mechanisms; regioselectivity
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Funding
- SMARTMIX CatchBio Program
- European Research Council [279549]
- Ministry of Education, Culture and Science [024.001.035]
- European Research Council (ERC) [279549] Funding Source: European Research Council (ERC)
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The palladium-catalyzed oxidation of alkenes, the Wacker-Tsuji reaction, is undoubtedly a classic in organic synthesis and provides reliable access to methyl ketones from terminal alkenes under mild reaction conditions. Methods that switch the selectivity of the reaction to provide the aldehyde product are desirable because of the access they provide to a valuable functional group, however such methods are elusive. Herein we survey both the methods which have been developed recently in achieving such selectivity and discuss common features and mechanistic insight which offers promise in achieving the goal of a general method for anti-Markovnikov-selective olefin oxidations.
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