Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 1, Pages 59-65Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2006.11.040
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The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them. Efforts in proteoglycomics exploring protein-binding properties and the enzymatic modification of carbohydrates have intensified, and synthetic tools, including activity- and affinity-based probes, have enhanced our understanding of the roles of carbohydrates in biology.
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